Rare diseases · Sign or symptom
Hand muscle weakness
HP:0030237
What it means
Reduced strength of the musculature of the hand.
Rare diseases that can present with this20
Common30–79%
10- Autosomal dominant Charcot-Marie-Tooth disease type 2A2
- Autosomal dominant spastic paraplegia type 41
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness
- Charcot-Marie-Tooth disease type 1E
- Charcot-Marie-Tooth disease type 1F
- Charcot-Marie-Tooth disease type 2B1
- Charcot-Marie-Tooth disease type 4A
- Chronic inflammatory demyelinating polyneuropathy
- X-linked Charcot-Marie-Tooth disease type 2
- X-linked Charcot-Marie-Tooth disease type 3
Sometimes5–29%
7- Autosomal dominant Charcot-Marie-Tooth disease type 2W
- Autosomal dominant Charcot-Marie-Tooth disease type 2Z
- Autosomal dominant spastic paraplegia type 17
- Autosomal dominant spastic paraplegia type 31
- Autosomal recessive progressive external ophthalmoplegia
- Charcot-Marie-Tooth disease type 4B2
- Neutral lipid storage disease with myopathy
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Hand muscle weakness
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.