Rare diseases · Sign or symptom
Focal friction-related palmoplantar hyperkeratosis
HP:0007497
What it means
Hyperkeratosis affecting the palm of the hand and the sole of the foot in areas exposed to friction.
Rare diseases that can present with this2
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hyperkeratosis, palmoplantar, focal friction-related
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.