Rare diseases · Sign or symptom
Palmoplantar hyperkeratosis
Thickening of the outer layer of the skin of the palms and soles
HP:0000972
What it means
Abnormal thickening of the skin localized to the palm of the hand and the sole of the foot.
The terms hyperkeratosis and keratoderma have been used interchangeably throughout the literature.
Rare diseases that can present with this19
Very common80–99%
5Common30–79%
10- Autosomal recessive generalized epidermolysis bullosa simplex
- Glycogen storage disease due to lactate dehydrogenase deficiency
- Haim-Munk syndrome
- Hereditary acrokeratotic poikiloderma
- Hidrotic ectodermal dysplasia
- Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome
- Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome
- Lelis syndrome
- Localized dystrophic epidermolysis bullosa, acral form
- Porokeratosis plantaris palmaris et disseminata
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hyperkeratosis of palms and soles · Hyperkeratosis of the palms and soles · Palmoplantar keratoses · Palmoplantar keratosis · Thick palms and soles · Thickened palms and soles
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.