Rare diseases · Sign or symptom
Elevated circulating alkaline phosphatase concentration
Elevated alkaline phosphatase
HP:0003155
What it means
Abnormally increased serum levels of alkaline phosphatase activity.
Rare diseases that can present with this41
Very common80–99%
5Common30–79%
25- Adult-onset Still disease
- Aggressive systemic mastocytosis
- Autosomal dominant hypophosphatemic rickets
- Budd-Chiari syndrome
- Caroli disease
- Caroli syndrome
- COG4-CDG
- Congenital bile acid synthesis defect type 2
- Congenital bile acid synthesis defect type 3
- Congenital hyperinsulinism due to HNF4A deficiency
- Cystinosis
- Enamel-renal syndrome
- Fibrous dysplasia of bone
- Hypocalcemic vitamin D-dependent rickets
- Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
- Isolated biliary atresia
- Metaphyseal chondrodysplasia, Jansen type
- Mirizzi syndrome
- Osteosarcoma
- Parenteral nutrition-associated cholestasis
- Primary biliary cholangitis
- Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations
- Senior-Boichis syndrome
- TAFRO syndrome
- Wild type ATTR amyloidosis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Elevated ALP · Greatly elevated alkaline phosphatase · High serum alkaline phosphatase · Hyperphosphatasemia · Hyperphosphatasia · Increased alkaline phosphatase · Increased serum alkaline phosphatase
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.