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Start free with EleplanIntrahepatic cholestasis of pregnancy
ORPHA:69665Disease
Also called Gravidic intrahepatic cholestasis · Pregnancy-related cholestasis · Recurrent intrahepatic cholestasis of pregnancy
What it is
Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by (i) pruritus with onset in the second or third trimester of pregnancy, (ii) elevated serum aminotransferases and bile acid levels, and (iii) spontaneous relief of signs and symptoms within two to three weeks after delivery.
Key facts
- Age of onset
- Adult
- Inheritance
- Multigenic/multifactorial, Not applicable
- Classified as
- Disease
Signs and symptoms
Common30–79%
3Sometimes5–29%
10- Abnormal circulating interleukin concentration
- Abnormal pineal melatonin secretion
- Depression
- Elevated circulating alkaline phosphatase concentration
- Hyperbilirubinemia
- Meconium stained amniotic fluid
- Neonatal respiratory distress
- Palmar pruritus
and 2 more in this range
Rare1–4%
10- Abdominal pain
- Abnormality of the pancreas
- Ascites
- Asterixis
- Cholecystitis
- Hypothyroidism
- Jaundice
- Premature birth
and 2 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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