Rare diseases · Sign or symptom
Dystrophic fingernails
Poor fingernail formation
HP:0008391
What it means
The presence of misshapen or partially destroyed nail plates, often with accumulation of soft, yellow keratin between the dystrophic nail plate and nail bed, resulting in elevation of the nail plate.
Rare diseases that can present with this19
Very common80–99%
7Common30–79%
7- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Cardiofaciocutaneous syndrome
- Cleft lip/palate-ectodermal dysplasia syndrome
- Hutchinson-Gilford progeria syndrome
- Localized dystrophic epidermolysis bullosa, acral form
- Localized dystrophic epidermolysis bullosa, nails only
- Transgrediens et progrediens palmoplantar keratoderma
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.