Rare diseases · Sign or symptom
Diffuse palmoplantar hyperkeratosis
HP:0007447
What it means
Diffuse abnormal thickening of the skin on the palms and soles.
The terms hyperkeratosis and keratoderma have been used interchangeably throughout the literature.
Rare diseases that can present with this9
Very common80–99%
7- CEDNIK syndrome
- Diffuse palmoplantar keratoderma-acrocyanosis syndrome
- Diffuse palmoplantar keratoderma, Bothnian type
- Ichthyosis hystrix of Curth-Macklin
- Keratosis palmaris et plantaris-clinodactyly syndrome
- KRT1-related diffuse nonepidermolytic keratoderma
- Transgrediens et progrediens palmoplantar keratoderma
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Diffuse palmoplantar keratoderma · Hyperkeratosis, diffuse palmoplantar
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.