Rare diseases · Sign or symptom
Demyelinating peripheral neuropathy
HP:0007108
What it means
Demyelinating neuropathy is characterized by slow nerve conduction velocities with reduced amplitudes of sensory/motor nerve conduction and prolonged distal latencies.
Rare diseases that can present with this26
Very common80–99%
7Common30–79%
12- Autosomal recessive spastic ataxia of Charlevoix-Saguenay
- Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome
- Charcot-Marie-Tooth disease type 1A
- Cockayne syndrome
- Cockayne syndrome type 3
- Early-onset spastic ataxia-myoclonic epilepsy-neuropathy syndrome
- Juvenile-onset diabetes mellitus-central and peripheral neurodegeneration syndrome
- Kjellin syndrome
- Mitochondrial neurogastrointestinal encephalomyopathy
- Polyendocrine-polyneuropathy syndrome
- Spastic paraplegia-neuropathy-poikiloderma syndrome
- Xeroderma pigmentosum-Cockayne syndrome complex
Sometimes5–29%
5The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.