Rare diseases · Sign or symptom
Decreased mitogen-induced T-cell proliferation
HP:0031381
What it means
Abnormal decrease of T cell proliferation in response to mitogenic stimuli. This is commonly measured through intracellular expression of Ki67, decreasing surface expression of carboxyfluorescein diacetate (CFSE), or 3H-thymidine incorporation. Length of incubation, specific stimulus and strength of stimulation may vary between laboratories.
A decreased proliferative response of T cells in vitro or in vivo, when stimulated with mitogens, such as phytohemagglutinin (PHA).
Rare diseases that can present with this11
Very common80–99%
4Common30–79%
5- Combined immunodeficiency with facio-oculo-skeletal anomalies
- Skeletal dysplasia-T-cell immunodeficiency-developmental delay syndrome
- T-B+NK+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta deficiency
- T-B-NK+ severe combined immunodeficiency due to complete RAG1/2 deficiency
- T-B+NK+ severe combined immunodeficiency due to IL-7Ralpha deficiency
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased lymphocyte proliferation in response to mitogen · Reduced lymphocyte proliferation to mitogen
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.