Rare diseases · Sign or symptom

Decreased circulating insulin-like growth factor-binding protein acid labile subunit concentration

HP:0045046

What it means

The concentration of insulin-like growth factor-binding protein acid labile subunit in the blood circulation is below the lower limit of normal.

Insulin-like growth factor binding protein, acid labile subunit, also known as IGFALS, is a protein which in humans is encoded by the IGFALS gene. {xref="wikipedia"}

Rare diseases that can present with this2

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Acid-labile subunit deficiency · Decreased insulin-like growth factor-binding protein complex acid labile subunit concentration · Decreased insulin-like growth factor-binding protein complex acid labile subunit level · Decreased insulin-like growth factor-binding protein complex acid labile subunit level in blood · Decreased levels of acid labile subunit · Reduced insulin like growth factor binding protein acid labile subunit level · Reduced insulin-like growth factor-binding protein complex acid labile subunit concentration · Reduced insulin-like growth factor-binding protein complex acid labile subunit level

Decreased circulating insulin-like growth…

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.