Rare diseases · Sign or symptom
Decreased circulating IgM concentration
HP:0002850
What it means
An abnormally decreased level of immunoglobulin M (IgM) in blood.
Rare diseases that can present with this18
Very common80–99%
3Common30–79%
6Sometimes5–29%
9- Autoimmune lymphoproliferative syndrome
- Hypohidrotic ectodermal dysplasia with immunodeficiency
- Intellectual disability-seizures-hypophosphatasia-ophthalmic-skeletal anomalies syndrome
- Primary intestinal lymphangiectasia
- Recurrent infections associated with rare immunoglobulin isotypes deficiency
- RIDDLE syndrome
- Secondary intestinal lymphangiectasia
- Skeletal dysplasia-T-cell immunodeficiency-developmental delay syndrome
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased IgM · Decreased IgM level · IgM deficiency · Reduced IgM levels
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.