Rare diseases · Sign or symptom

Decreased circulating IgG2 concentration

HP:0008348

What it means

A reduction in immunoglobulin levels of the IgG2 subclass in the blood circulation.

Rare diseases that can present with this3

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Decreased circulating IgG2 level · Decreased IgG2 level in blood · Immunoglobulin IgG2 deficiency · Reduced IgG2 levels

Decreased circulating IgG2 concentration

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.