Rare diseases · Sign or symptom
Decreased circulating aldosterone concentration
Low blood aldosterone level
HP:0004319
What it means
Abnormally reduced levels of aldosterone.
Aldosterone is a hormone that is produce by the adrenal cortex and that acts on the distal tubules and collecting ducts to favor retention of sodium excretion of potassium, and increased water retention, thereby tending to increase blood pressure. Aldosterone is sometimes called a mineralocorticoid because of its influence on sodium homeostasis.
Rare diseases that can present with this15
Very common80–99%
5Common30–79%
7- Acute adrenal insufficiency
- Addison disease
- Apparent mineralocorticoid excess
- Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
- Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency
- Congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency
- Early-onset familial hypoaldosteronism
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased aldosterone · Decreased aldosterone production · Decreased serum aldosterone · Hypoaldosteronism · Mineralocorticoid insufficiency
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.