Rare diseases · Sign or symptom
Coarctation of aorta
Narrowing of aorta
HP:0001680
What it means
Coarctation of the aorta is a narrowing or constriction of a segment of the aorta.
Coarctation refers to a narrowing of the lumen of a vessel producing an obstruction to flow. Coarctation can occur in any region of the aorta. Coarctation of the aorta is often a discrete obstruction commonly located in the descending thoracic aorta. More specifically, it is usually located in the juxtaductal position immediately distal to the left-subclavian artery in a left-sided arch. The hallmark clinical finding in coarctation of the aorta is hypertension proximal to the lesion, with diminished blood pressure distal to the obstruction. Consequently, clinical diagnosis can be made by the presence of diminished lower extremity pulses, differences in timing between upper extremity central pulses (often brachial) and lower extremity central pulses (often femoral), or the presence of a supine arm-leg blood pressure gradient.
Rare diseases that can present with this65
Common30–79%
9Sometimes5–29%
42- 16p13.11microduplication syndrome
- 17q11microdeletion syndrome
- 45,X/46,XY mixed gonadal dysgenesis
- 8q24.3microdeletion syndrome
- Absence of the pulmonary artery
- Acrocardiofacial syndrome
- Autosomal dominant cutis laxa
- Blomstrand lethal chondrodysplasia
and 34 more in this range
Rare1–4%
13- 15q11.2microdeletion syndrome
- Abnormal origin of right or left pulmonary artery from the aorta
- Congenital total pulmonary venous return anomaly
- Craniofaciofrontodigital syndrome
- Diamond-Blackfan anemia
- Esophageal atresia
- Fatal infantile lactic acidosis with methylmalonic aciduria
- Floating-Harbor syndrome
and 5 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Aortic coarctation · Coarctation of the aorta · Narrowing of the aorta
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.