Rare diseases · Sign or symptom
Bilateral tonic-clonic seizure with generalized onset
HP:0025190
What it means
A bilateral tonic-clonic seizure with generalized onset is a type of bilateral tonic-clonic seizure characterized by generalized onset; these seizures rapidly engage networks in both hemispheres at the start of the seizure.
Rare diseases that can present with this13
Common30–79%
5Sometimes5–29%
7- Angelman syndrome due to paternal uniparental disomy of chromosome 15
- GM1 gangliosidosis
- Pontocerebellar hypoplasia type 2
- Rasmussen syndrome
- Ring chromosome 21 syndrome
- Severe neonatal hypotonia-seizures-encephalopathy syndrome due to 5q31.3 microdeletion
- Spinal muscular atrophy-progressive myoclonic epilepsy syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Bilateral tonic-clonic seizure with generalised onset · Generalised tonic-clonic seizure without focal onset · Generalised tonic-clonic seizure without partial onset · Generalised tonic-clonic seizures without focal onset · Generalised-onset tonic-clonic seizure · Generalized tonic-clonic seizure without focal onset · Generalized tonic-clonic seizure without partial onset · Generalized tonic-clonic seizures without focal onset
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.