Rare diseases · Sign or symptom
Abnormality of the cardiovascular system
Cardiovascular abnormality
HP:0001626
What it means
Any abnormality of the cardiovascular system.
The cardiovascular system consists of the heart, vasculature, and the lymphatic system.
Rare diseases that can present with this39
Very common80–99%
4Common30–79%
12- Cushing disease
- Cushing syndrome due to ectopic ACTH secretion
- FATCO syndrome
- Fucosidosis
- Isolated succinate-CoQ reductase deficiency
- ISPD-related limb-girdle muscular dystrophy R20
- Miller-Dieker syndrome
- Multicentric osteolysis-nodulosis-arthropathy spectrum
- Oculoectodermal syndrome
- Paris-Trousseau thrombocytopenia
- Silver-Russell syndrome due to a point mutation
- Sirenomelia
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Cardiovascular disease
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.