Rare diseases · Sign or symptom
2-3 toe syndactyly
Webbed 2nd and 3rd toes
HP:0004691
What it means
Syndactyly with fusion of toes two and three.
Rare diseases that can present with this40
Very common80–99%
7Common30–79%
10- Brachydactyly type A7
- Developmental and speech delay due to SOX5 deficiency
- Fallot complex-intellectual disability-growth delay syndrome
- Feingold syndrome type 1
- MEND syndrome
- Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome
- Oculofaciocardiodental syndrome
- Ring chromosome 22 syndrome
- Syndactyly type 5
- Van den Ende-Gupta syndrome
Sometimes5–29%
18- 16p12.1p12.3triplication syndrome
- Andersen-Tawil syndrome
- Basel-Vanagaite-Smirin-Yosef syndrome
- CTCF-related neurodevelopmental disorder
- Distal deletion 12q syndrome
- Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome
- Intellectual disability-balding-patella luxation-acromicria syndrome
- Intellectual disability-cardiac anomalies-short stature-joint laxity syndrome
and 10 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: 2-3 syndactyly of feet · 2-3 toe soft tissue syndactyly · 2-3 toes syndactyly · partial or complete syndactyly 2nd-3rd toes · Syndactyly of second and third toes · Toe syndactyly, 2-3
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.