Rare diseases · Sign or symptom
Premature birth
Premature delivery of affected infants
HP:0001622
What it means
The birth of a baby of less than 37 weeks of gestational age.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this119
Very common80–99%
28- Axial mesodermal dysplasia spectrum
- Blomstrand lethal chondrodysplasia
- Bronchopulmonary dysplasia
- Congenital toxoplasmosis
- Diethylstilbestrol syndrome
- Distal 22q11.2 microdeletion syndrome
- Distal deletion 17q syndrome
- Double uterus-hemivagina-renal agenesis syndrome
- Ebstein malformation of the tricuspid valve
- Fibular aplasia-ectrodactyly syndrome
- Fibulo-ulnar hypoplasia-renal anomalies syndrome
- Hydrolethalus
- Ichthyosis-prematurity syndrome
- Indomethacin embryofetopathy
- Microcephalic osteodysplastic primordial dwarfism types I and III
- Multifocal infantile hemangioma with extracutenous involvement
- Necrotizing enterocolitis
- Omphalocele
- Pelizaeus-Merzbacher disease
- Pemphigoid gestationis
- Radioulnar synostosis-microcephaly-scoliosis syndrome
- Renal tubular dysgenesis
- Restrictive dermopathy
- Retinopathy of prematurity
- Schisis association
- Sepsis in premature infants
- Splenogonadal fusion-limb defects-micrognathia syndrome
- VACTERL/VATER association
Common30–79%
52- 46,XY difference of sex development-adrenal insufficiency due to CYP11A1 deficiency
- Acitretin/etretinate embryopathy
- ALG8-CDG
- Antiphospholipid syndrome
- Autosomal dominant myopia-midfacial retrusion-sensorineural hearing loss-rhizomelic dysplasia syndrome
- Bartter syndrome type 4
- Beckwith-Wiedemann syndrome
- Cardiofaciocutaneous syndrome
- Cerebral visual impairment
- Congenital analbuminemia
- Congenital heart block
- Congenital herpes simplex virus infection
- Congenital-onset Steinert myotonic dystrophy
- Congenital plasminogen activator inhibitor type 1 deficiency
- Congenital syphilis
- Congenital tricuspid valve dysplasia
- Cornelia de Lange syndrome
- Corneodermatoosseous syndrome
- Craniofaciofrontodigital syndrome
- Dermatosparaxis Ehlers-Danlos syndrome
- Duodenal atresia
- FATCO syndrome
- FG syndrome type 1
- Fumaric aciduria
- Galloway-Mowat syndrome
- GMS syndrome
- HEC syndrome
- Holoprosencephaly-caudal dysgenesis syndrome
- Imperforate oropharynx-costovertebral anomalies syndrome
- Inherited isolated adrenal insufficiency due to partial CYP11A1 deficiency
- Jacobsen syndrome
- Kagami-Ogata syndrome
- Kagami-Ogata syndrome due to paternal uniparental disomy of chromosome 14
- Lower limb malformation-hypospadias syndrome
- Microform holoprosencephaly
- Mosaic trisomy 16 syndrome
- Multicystic dysplastic kidney
- Oligomeganephronia
- Pachygyria-intellectual disability-epilepsy syndrome
- Parenteral nutrition-associated cholestasis
- Pediatric acute respiratory distress syndrome
- Ptosis-vocal cord paralysis syndrome
- Pulmonary atresia-intact ventricular septum syndrome
- Pyridoxamine-5-phosphate deficiency-developmental and epileptic encephalopathy
- Roberts syndrome
- Schimke immuno-osseous dysplasia
- Silver-Russell syndrome
- Temple syndrome
- Temple syndrome due to maternal uniparental disomy of chromosome 14
- Vascular Ehlers-Danlos syndrome
- Velo-facial-skeletal syndrome
- X-linked centronuclear myopathy
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Premature delivery · Preterm birth · Preterm delivery · Shortened gestation time
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.