Rare diseases · Sign or symptom
Inability to walk
HP:0002540
What it means
Incapability to ambulate.
Rare diseases that can present with this106
Very common80–99%
13- Atypical juvenile parkinsonism
- Autosomal recessive myogenic arthrogryposis multiplex congenita
- Autosomal recessive spastic paraplegia type 57
- Autosomal spastic paraplegia type 18
- Basel-Vanagaite-Smirin-Yosef syndrome
- Epilepsy of infancy with migrating focal seizures
- FLNC-related handgrip and calf weakness-distal myopathy
- Laminin subunit alpha 2-related congenital muscular dystrophy
- Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome
- Northern epilepsy
- PRUNE1-related neurological syndrome
- PYCR2-related microcephaly-progressive leukoencephalopathy
- Severe Canavan disease
Common30–79%
35- 9q33.3q34.11microdeletion syndrome
- Alacrimia-choreoathetosis-liver dysfunction syndrome
- Alobar holoprosencephaly
- Atypical Rett syndrome
- Autosomal recessive spastic paraplegia type 11
- Bohring-Opitz syndrome
- Charcot-Marie-Tooth disease type 4A
- Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder
- Classic pantothenate kinase-associated neurodegeneration
- Congenital lactic acidosis, Saguenay-Lac-Saint-Jean type
- Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation
- Distal myotilinopathy
- DNM1L-related encephalopathy due to mitochondrial and peroxisomal fission defect
- Early-onset seizures-distal limb anomalies-facial dysmorphism-global developmental delay syndrome
- Focal stiff limb syndrome
- Hereditary motor and sensory neuropathy, Okinawa type
- Infantile-onset axonal motor and sensory neuropathy-optic atrophy-neurodegenerative syndrome
- Juvenile amyotrophic lateral sclerosis
- KCNQ2-related developmental and epileptic encephalopathy
- Lafora disease
- Microcephaly-intellectual disability-sensorineural hearing loss-epilepsy-abnormal muscle tone syndrome
- Midline interhemispheric variant of holoprosencephaly
- Mucolipidosis type II
- Mucopolysaccharidosis-like syndrome with congenital heart defects and hematopoietic disorders
- Myopathy and diabetes mellitus
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutation
- Pelizaeus-Merzbacher disease, connatal form
- Proximal spinal muscular atrophy
- PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome
- Semilobar holoprosencephaly
- SLC35A2-CDG
- SLC39A8-CDG
- TBCK-related encephalopathy-severe hypotonia-craniofacial dysmorphism syndrome
- TELO2-related intellectual disability-neurodevelopmental disorder
Sometimes5–29%
32- Adenylosuccinate synthetase-like 1-related distal myopathy
- Angelman syndrome
- Autosomal dominant Charcot-Marie-Tooth disease type 2E
- Autosomal dominant Charcot-Marie-Tooth disease type 2Z
- Autosomal recessive cutis laxa type 2A
- Bainbridge-Ropers syndrome
- Charcot-Marie-Tooth disease type 1E
- Charcot-Marie-Tooth disease type 2B1
and 24 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Non-ambulatory
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.