Rare diseases · Sign or symptom
Strabismus
Cross-eyed
HP:0000486
What it means
A misalignment of the eyes so that the visual axes deviate from bifoveal fixation. The classification of strabismus may be based on a number of features including the relative position of the eyes, whether the deviation is latent or manifest, intermittent or constant, concomitant or otherwise and according to the age of onset and the relevance of any associated refractive error.
Rare diseases that can present with this503
Very common80–99%
62- 6q terminal deletion syndrome
- Alpha-N-acetylgalactosaminidase deficiency type 3
- Aniridia-renal agenesis-psychomotor retardation syndrome
- Ataxia-deafness-intellectual disability syndrome
- Ataxia-telangiectasia
- Autosomal recessive spastic paraplegia type 44
- Autosomal recessive spastic paraplegia type 78
- Branchiogenic deafness syndrome
- Branchioskeletogenital syndrome
- Camptodactyly-joint contractures-facial skeletal defects syndrome
- Cartilage-hair hypoplasia
- CHIME syndrome
- Christianson syndrome
- CK syndrome
- Coats disease
- Congenital cataract-hypertrophic cardiomyopathy-mitochondrial myopathy syndrome
- Congenital cataracts-facial dysmorphism-neuropathy syndrome
- Congenital fibrosis of extraocular muscles
- Cryptorchidism-arachnodactyly-intellectual disability syndrome
- Deaf blind hypopigmentation syndrome, Yemenite type
- Delayed speech-facial asymmetry-strabismus-ear lobe creases syndrome
- Duane retraction syndrome
- FOXG1 syndrome
- Frontonasal dysplasia-alopecia-genital anomalies syndrome
- Gaucher disease type 2
- Gaucher disease type 3
- German syndrome
- Haddad syndrome
- Holoprosencephaly-craniosynostosis syndrome
- Hypotonia-speech impairment-severe cognitive delay syndrome
- Infantile choroidocerebral calcification syndrome
- Intellectual disability-seizures-hypophosphatasia-ophthalmic-skeletal anomalies syndrome
- Intellectual disability-seizures-macrocephaly-obesity syndrome
- Intellectual disability-strabismus syndrome
- Isolated complete colobomatous microphthalmia
- Isolated complex I deficiency
- IVIC syndrome
- Marinesco-Sjögren syndrome
- McDonough syndrome
- Microbrachycephaly-ptosis-cleft lip syndrome
- Mietens syndrome
- Moebius syndrome
- Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome
- Monosomy 9q22.3 syndrome
- Morning glory disc anomaly
- Mucolipidosis type IV
- Muscle-eye-brain disease
- Neonatal adrenoleukodystrophy
- Non-distal deletion 10q syndrome
- Oculocutaneous albinism type 1B
- PMM2-CDG
- Progeroid syndrome, Petty type
- Pseudoxanthoma elasticum-like skin manifestations with retinitis pigmentosa
- Radioulnar synostosis-developmental delay-hypotonia syndrome
- Schizencephaly
- Severe oculo-renal-cerebellar syndrome
- SSR4-CDG
- Visceral neuropathy-brain anomalies-facial dysmorphism-developmental delay syndrome
- X-linked intellectual disability-Dandy-Walker malformation-basal ganglia disease-seizures syndrome
- X-linked intellectual disability-hypogonadism-ichthyosis-obesity-short stature syndrome
- X-linked intellectual disability, Shrimpton type
- X small rings syndrome
Common30–79%
17- 10q22.3q23.3microduplication syndrome
- 19p13.13microdeletion syndrome
- 1p36deletion syndrome
- 1q44microdeletion syndrome
- 2p15p16.1microdeletion syndrome
- 2q23.1microduplication syndrome
- 48,XXXY syndrome
- 48,XXYY syndrome
- 49,XXXXY syndrome
- 6p22microdeletion syndrome
- 6q16microdeletion syndrome
- 8q21.11microdeletion syndrome
- 9q33.3q34.11microdeletion syndrome
- Acro-renal-ocular syndrome
- Adams-Oliver syndrome
- AHDC1-related intellectual disability-obstructive sleep apnea-mild dysmorphism syndrome
- ALG1-CDG
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Squint · Squint eyes
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.