Z16

Non-billable

Resistance to antimicrobial drugs

Z16 is the ICD-10-CM code for Resistance to antimicrobial drugs. It is a non-billable category code — use a more specific child code such as Z16.1 for billing.

Status
Header (non-billable)
Chapter
Z00-Z99
Subcodes
3
Edition
FY2026

Z00-Z99 Factors influencing health status and contact with health services

Excludes1 — not coded here

  • Methicillin resistant Staphylococcus aureus infection (A49.02)
  • Methicillin resistant Staphylococcus aureus pneumonia (J15.212)
  • Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02)

Code first

  • the infection

Notes

  • The codes in this category are provided for use as additional codes to identify the resistance and non-responsiveness of a condition to antimicrobial drugs.

Frequently asked questions

What is ICD-10 code Z16?
Z16 is the ICD-10-CM code for "Resistance to antimicrobial drugs". It falls under Z00-Z99 Factors influencing health status and contact with health services.
Is Z16 a billable code?
No — Z16 is a non-billable header code. Use a more specific child code (such as Z16.1) for billing.
What are the subcodes of Z16?
Z16 has 3 more specific child codes, including Z16.1, Z16.2, Z16.3.
What is excluded from Z16?
Excludes1 (not coded here): Methicillin resistant Staphylococcus aureus infection (A49.02); Methicillin resistant Staphylococcus aureus pneumonia (J15.212); Sepsis due to Methicillin resistant Staphylococcus aureus (A41.02).

Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.

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