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Non-billableOther systemic involvement of connective tissue
M35 is the ICD-10-CM code for Other systemic involvement of connective tissue. It is a non-billable category code — use a more specific child code such as M35.0 for billing.
- Status
- Header (non-billable)
- Chapter
- M00-M99
- Subcodes
- 10
- Edition
- FY2026
M00-M99 Diseases of the musculoskeletal system and connective tissue
What this means — in plain language
MedlinePlus · NIHYour connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue. Over 200 disorders that impact connective tissue. There are different types:…
Read more about Connective Tissue Disorders at MedlinePlus ↗Source: U.S. National Library of Medicine (MedlinePlus). Informational only — not medical advice.
Excludes1 — not coded here
- •reactive perforating collagenosis (L87.1)
Medications indicated for this condition
FDA labeling- Baptisia Tinctoria, Echinacea (angustifolia), Arsenicum Album, Chininum Sulphuricum, Crotalus Horridus, Lachesis Mutus, Secale Cornutum, Tarentula Cubensis, Latrodectus Mactans, Anthracinum, Loxosceles Reclusa›
- Pilocarpine Hydrchloride›
- SarilumabInterleukin-6 Receptor Antagonist [EPC]›
Drugs whose FDA labeling lists this condition's category among its indications. Informational only — not a treatment recommendation or medical advice.
Conditions mapped to this code
MedlinePlus · NIHPlain-language health-topic references grounded in MedlinePlus (NIH/NLM).
18 rare diseases filed under this code
Orphanet · INSERMICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. This code is shared — showing 12 of 18.
Orphadata Science: Free access data from Orphanet. © INSERM 1999. 3 of these are exact ICD-10 matches; the rest are broader-bucket mappings.
Frequently asked questions
- What is ICD-10 code M35?
- M35 is the ICD-10-CM code for "Other systemic involvement of connective tissue". It falls under M00-M99 Diseases of the musculoskeletal system and connective tissue.
- Is M35 a billable code?
- No — M35 is a non-billable header code. Use a more specific child code (such as M35.0) for billing.
- What is excluded from M35?
- Excludes1 (not coded here): reactive perforating collagenosis (L87.1).
Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.
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