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Start free with EleplanZinc-responsive necrolytic acral erythema
ORPHA:439196Particular clinical situation in a disease or syndrome
Also called Necrolytic acral erythema · NAE
What it is
A rare skin disease characterized initially by erythematous patches with superficial necrosis, at later stages by hyperkeratotic plaques with a rim of dusky erythema, of exclusively acral distribution with a predilection for the lower extremities, and universal association with hepatitis C virus infection. Patients typically experience pruritus or pain. Serum zinc levels may or may not be decreased, although oral zinc supplementation often improves the condition.
Key facts
- Age of onset
- All ages
- Inheritance
- Not applicable
- Classified as
- Particular clinical situation in a disease or syndrome
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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