Rare diseases · Sign or symptom
Unconjugated hyperbilirubinemia
HP:0008282
What it means
An increased amount of unconjugated (indirect) bilurubin in the blood.
Rare diseases that can present with this13
Very common80–99%
4Common30–79%
8- Athyreosis
- Autoimmune hemolytic anemia, warm type
- Congenital erythropoietic porphyria
- Hemolytic anemia due to glucophosphate isomerase deficiency
- Immune-mediated thrombotic thrombocytopenic purpura
- Paroxysmal nocturnal hemoglobinuria
- Shiga toxin-associated hemolytic uremic syndrome
- Southeast Asian ovalocytosis
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.