Rare diseases · Sign or symptom
Tricuspid regurgitation
HP:0005180
What it means
Failure of the tricuspid valve to close sufficiently upon contraction of the right ventricle, causing blood to regurgitate (flow backward) into the right atrium.
This term should not be applied to Ebstein's anomaly of the tricuspid valve (see HP:0010316).
Rare diseases that can present with this46
Common30–79%
12- Anophthalmia-megalocornea-cardiopathy-skeletal anomalies syndrome
- Atrial septal defect, ostium primum type
- Cardiac-valvular Ehlers-Danlos syndrome
- Congenital tricuspid stenosis
- Congenital tricuspid valve dysplasia
- Ebstein malformation of the tricuspid valve
- Familial idiopathic dilatation of the right atrium
- GMS syndrome
- Idiopathic pulmonary arterial hypertension
- Isolated right ventricular hypoplasia
- Ptosis-upper ocular movement limitation-absence of lacrimal punctum syndrome
- Uhl anomaly
Sometimes5–29%
27- 15q overgrowth syndrome
- 16p11.2p12.2microdeletion syndrome
- ALG9-CDG
- Aortic arch interruption
- Atrial septal defect, ostium secundum type
- Atrial septal defect, sinus venosus type
- Carcinoid syndrome
- Cardiac anomalies-short stature-joint hypermobility-facial dysmorphism syndrome
and 19 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Tricuspid insufficiency · Tricuspid valve regurgitation
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.