Rare diseases · Sign or symptom

Transverse terminal limb defect

HP:6000818

What it means

A congenital anomaly that appears as an amputation at different levels of the extremity. The limb is missing the terminal (distal) segment(s), with preservation of all the segment(s) proximal to the missing segment.

Terminal transverse limb deficiency is a congenital anomaly that appears as an amputation at different levels of a limb. The limb is missing the terminal (distal) segment(s), with preservation of all the segment(s) proximal to the missing segment.

Rare diseases that can present with this1

Sometimes5–29%

1

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Transverse terminal limb reduction

Transverse terminal limb defect

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.