Rare diseases · Sign or symptom

Subcutaneous calcification

Skin calcification

HP:0007618

What it means

Deposition of calcium salts in subcutaneous tissue (i.e., the the lowermost layer of the integument).

Rare diseases that can present with this5

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Subcutaneous calcification

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.