Rare diseases · Sign or symptom

Stomatitis

Inflammation of the mouth

HP:0010280

What it means

Stomatitis is an inflammation of the mucous membranes of any of the structures in the mouth.

Principal causative agents include herpes simplex virus (HSV), which causes recurrent herpetic stomatitis particularly in T-cell deficiencies, and Coxsackievirus (hand-foot-and-mouth disease), which may be unusually severe or prolonged in antibody deficiencies.

Rare diseases that can present with this10

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Gingivostomatitis

Stomatitis

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.