Spicular pigmentation of the retina

What it means

Pigment migration into the retina in a bone-spicule configuration (resembling the nucleated cells within the lacuna of bone).

Spicular pigmentation of the retina is typically associated with migration of microglia or retinal pigment epithelial cells into the neuroretina secondary to photoreceptor cell death; melanin from these cells causes the pigmentary changes.

Rare diseases that can present with this4

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Bone corpuscle fundus pigmentation · Bone spicule pigmentation of the retina · Fundus with peripheral bony spicules · Retinal 'bone corpuscle' pigmentation · Retinal bone corpuscle pigmentation · Retinal pigmented bone spicules