Rare diseases · Sign or symptom
Spastic tetraplegia
HP:0002510
What it means
Spastic paralysis affecting all four limbs.
Rare diseases that can present with this25
Very common80–99%
2Common30–79%
9- Bilateral generalized polymicrogyria
- COG2-CDG
- Early-onset progressive leukoencephalopathy-central nervous system calcification-deafness-visual impairment syndrome
- Familial acute necrotizing encephalopathy
- Fucosidosis
- Northern epilepsy
- Oculocerebral hypopigmentation syndrome, Cross type
- Schizencephaly
- Unilateral polymicrogyria
Sometimes5–29%
13- 3-phosphoglycerate dehydrogenase deficiency, infantile/juvenile form
- Aicardi-Goutières syndrome
- Allan-Herndon-Dudley syndrome
- Autosomal recessive methemoglobinemia
- Bilateral perisylvian polymicrogyria
- Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation
- Early-onset seizures-distal limb anomalies-facial dysmorphism-global developmental delay syndrome
- Hypotonia-speech impairment-severe cognitive delay syndrome
and 5 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Spastic quadriplegia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.