Rare diseases · Sign or symptom

Severely increased total eosinophil count

HP:0032061

What it means

Severe increase in circulating eosinophils, usually characterized as more than 1500 eosinophils per microlitre.

Typically eosinophils in the blood are less than 0.5 billion cells per liter, corresponding to less than 5 percent of leukocytes. This term refers to a marked degree of eosinophilia with more than 1.5 billion cells per liter.

Rare diseases that can present with this6

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Hypereosinophilia

Severely increased total eosinophil count

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.