Rare diseases · Sign or symptom
Sensory neuropathy
Damage to nerves that sense feeling
HP:0000763
What it means
Peripheral neuropathy affecting the sensory nerves.
Rare diseases that can present with this39
Very common80–99%
9- Arachnoiditis
- Buerger disease
- Congenital cataracts-facial dysmorphism-neuropathy syndrome
- Krabbe disease
- Multiple sclerosis-ichthyosis-factor VIII deficiency syndrome
- Spinal arteriovenous metameric syndrome
- X-linked Charcot-Marie-Tooth disease type 1
- X-linked Charcot-Marie-Tooth disease type 4
- X-linked Charcot-Marie-Tooth disease type 5
Common30–79%
8- Alpha-N-acetylgalactosaminidase deficiency type 1
- Ataxia with vitamin E deficiency
- Autosomal recessive spastic paraplegia type 25
- Autosomal recessive spinocerebellar ataxia-blindness-deafness syndrome
- Classical-like Ehlers-Danlos syndrome type 1
- NARP syndrome
- Spinocerebellar ataxia type 25
- Wild type ATTR amyloidosis
Sometimes5–29%
21- AGel amyloidosis
- Autosomal dominant cerebellar ataxia-deafness-narcolepsy syndrome
- Autosomal dominant optic atrophy plus syndrome
- Camurati-Engelmann disease
- Chédiak-Higashi syndrome
- Combined oxidative phosphorylation defect type 13
- Congenital bile acid synthesis defect type 4
- Deafness-enamel hypoplasia-nail defects syndrome
and 13 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Peripheral sensory neuropathy
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.