Rare diseases · Sign or symptom
Second ray metatarsophalangeal synostosis
Fused innermost bone of 2nd toe with the 2nd long bone of foot
HP:0100483
What it means
Congenital fusion of the second metatarsal bone with the proximal phalanx of the second toe.
Rare diseases that can present with this1
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.