Rare diseases · Sign or symptom
Sandal gap
Gap between 1st and 2nd toes
HP:0001852
What it means
A widely spaced gap between the first toe (the great toe) and the second toe.
Rare diseases that can present with this54
Very common80–99%
9Common30–79%
21- 2q23.1microdeletion syndrome
- 2q31.1microdeletion syndrome
- 8q22.1microdeletion syndrome
- Acrootoocular syndrome
- Acro-renal-ocular syndrome
- Atelosteogenesis type II
- Beta-mercaptolactate cysteine disulfiduria
- Brachydactyly type A7
- CLOVES syndrome
- Craniofrontonasal dysplasia
- CTCF-related neurodevelopmental disorder
- Diastrophic dysplasia
- Down syndrome
- Dubowitz syndrome
- Hydrocephalus-costovertebral dysplasia-Sprengel anomaly syndrome
- Menke-Hennekam syndrome
- Microcephaly-cardiomyopathy syndrome
- Nicolaides-Baraitser syndrome
- Severe oculo-renal-cerebellar syndrome
- X-linked intellectual disability, Cabezas type
- Zechi-Ceide syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Gap between first and second toe · Increased space between first and second toes · Sandal gap between first and second toes · Space between great toe and second toe · Wide space between 1st, 2nd toes · Wide space between first and second toes · Wide-spaced big toe · Widely spaced 1st-2nd toes
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.