Rare diseases · Sign or symptom
Reduced subcutaneous adipose tissue
Reduced fat tissue below the skin
HP:0003758
What it means
A reduced amount of fat tissue in the lowest layer of the integument. This feature can be appreciated by a reduced skinfold thickness.
Rare diseases that can present with this16
Very common80–99%
12- Autosomal semi-dominant severe lipodystrophic laminopathy
- Centrifugal lipodystrophy
- Donohue syndrome
- Drug-induced localized lipodystrophy
- Idiopathic localized lipodystrophy
- Lipodystrophy due to peptidic growth factors deficiency
- Panniculitis-induced localized lipodystrophy
- PLIN1-related familial partial lipodystrophy
- Pressure-induced localized lipoatrophy
- Progeroid syndrome, Petty type
- Progressive encephalopathy-severe neurodegeneration-lipodystrophy syndrome
- Wiedemann-Rautenstrauch syndrome
Common30–79%
3The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased subcutaneous adipose tissue · Decreased subcutaneous fat · Reduced subcutaneous fat · Scanty adipose tissue
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.