Rare diseases · Sign or symptom
Reduced eye contact
Poor eye contact
HP:0000817
What it means
A reduced frequency or duration of eye contact.
Eye contact, defined as the meeting of the gaze between two people during a conversation, is an important form of nonverbal communication.
Rare diseases that can present with this25
Very common80–99%
4Common30–79%
9- 2q23.1microduplication syndrome
- CDKL5-deficiency disorder
- Combined oxidative phosphorylation defect type 39
- Early-onset epileptic encephalopathy-cortical blindness-intellectual disability-facial dysmorphism syndrome
- FOXG1 syndrome
- Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome
- Microcephaly-intellectual disability-sensorineural hearing loss-epilepsy-abnormal muscle tone syndrome
- RARS-related autosomal recessive hypomyelinating leukodystrophy
- X-linked intellectual disability-cerebellar hypoplasia syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.