Rare diseases · Sign or symptom
Recurrent bacterial infections
Bacterial infections, recurrent
HP:0002718
What it means
Increased susceptibility to bacterial infections as manifested by recurrent episodes of bacterial infection.
Rare diseases that can present with this29
Very common80–99%
9- Autosomal dominant severe congenital neutropenia
- Chédiak-Higashi syndrome
- Combined immunodeficiency due to CRAC channel dysfunction
- Combined immunodeficiency due to ZAP70 deficiency
- Hypohidrotic ectodermal dysplasia with immunodeficiency
- Infantile systemic hyalinosis
- Leukocyte adhesion deficiency
- Transient predisposition to invasive pyogenic bacterial infection
- X-linked severe congenital neutropenia
Common30–79%
13- Adult idiopathic neutropenia
- Combined immunodeficiency with facio-oculo-skeletal anomalies
- Glutathione synthetase deficiency
- Glycogen storage disease due to glucose-6-phosphatase deficiency type Ib
- Ichthyosis follicularis-alopecia-photophobia syndrome
- Immunodeficiency by defective expression of MHC class II
- PGM3-CDG
- Recurrent infections associated with rare immunoglobulin isotypes deficiency
- T-B-NK+ severe combined immunodeficiency due to complete RAG1/2 deficiency
- T-B-NK+ severe combined immunodeficiency due to DCLRE1C deficiency
- T-B+NK- severe combined immunodeficiency due to gamma chain deficiency
- T-cell immunodeficiency with thymic aplasia
- WHIM syndrome
Sometimes5–29%
4The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Frequent bacterial infections · Frequent pyogenic infections · Increased susceptibility to bacterial infections · Prone to bacterial infection · Recurrent major bacterial infections · Recurrent pyogenic infections · Susceptibility to pyogenic infection
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.