Rare diseases · Sign or symptom
Prominent supraorbital ridges
Prominent brow
HP:0000336
What it means
Greater than average forward and/or lateral protrusion of the supraorbital portion of the frontal bones.
Rare diseases that can present with this24
Very common80–99%
10- Atkin-Flaitz syndrome
- Craniolenticulosutural dysplasia
- Frontometaphyseal dysplasia
- McDonough syndrome
- Melnick-Needles syndrome
- Otopalatodigital syndrome type 1
- Otopalatodigital syndrome type 2
- Wilson-Turner syndrome
- X-linked intellectual disability, Cilliers type
- X-linked intellectual disability, Shashi type
Common30–79%
8- Acromegaly
- Alpha-mannosidosis
- Borjeson-Forssman-Lehmann syndrome
- Cantú syndrome
- Macrocephaly-spastic paraplegia-dysmorphism syndrome
- Non-syndromic metopic craniosynostosis
- X-linked intellectual disability-global development delay-facial dysmorphism-sacral caudal remnant syndrome
- X-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hyperplasia of supraorbital margins · Hyperplasia of supraorbital ridge · Hypertrophy of supraorbital margins · Hypertrophy of supraorbital ridge · Prominent supraorbital margins · Prominent supraorbital ridge · Protruding supraorbital ridge · Supraorbital hyperostosis
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.