Rare diseases · Sign or symptom
Prominent nasolabial fold
Deep laugh lines
HP:0005272
What it means
Exaggerated bulkiness of the crease or fold of skin running from the lateral margin of the nose, where nasal base meets the skin of the face, to a point just lateral to the corner of the mouth (cheilion, or commissure).
Rare diseases that can present with this8
Very common80–99%
4The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Deep nasolabial crease · Deep nasolabial fold · Deep nasolabial groove · Deep smile lines · Nasolabial crease, prominent · Prominent laugh lines · Prominent nasolabial groove · Prominent smile lines
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.