Rare diseases · Sign or symptom
Polydactyly
More than five fingers or toes on hands or feet
HP:0010442
What it means
A congenital anomaly characterized by the presence of supernumerary fingers or toes.
Rare diseases that can present with this28
Sometimes5–29%
15- 20p13microdeletion syndrome
- 9q21.13microdeletion syndrome
- CLOVES syndrome
- DYRK1A-related intellectual disability syndrome
- Focal dermal hypoplasia
- Helsmoortel-Van der Aa syndrome
- Isolated rhombencephalosynapsis
- Isolated tibial hemimelia
and 7 more in this range
Rare1–4%
10- CHARGE syndrome
- CHILD syndrome
- Choanal atresia
- Combined pituitary hormone deficiencies, genetic forms
- Congenital sialidosis type 2
- DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion
- Fatal infantile lactic acidosis with methylmalonic aciduria
- Isolated absence of upper arm and forearm with hand present
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.