Rare diseases · Sign or symptom

Personality disorder

HP:0012075

What it means

A personality disorder is a deeply ingrained pattern of behavior of a specified kind that deviates markedly from the norms of generally accepted behavior. It is typically apparent by the time of adolescence and causes long-term difficulties in personal relationships or functioning in society.

A personality disorder is generally associated with significant problems and limitations in relationships, social encounters, work, and school. It usually manifests since childhood or adolescence and continues throughout adulthood.

In everyday care

Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:

Rare diseases that can present with this4

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Personality disorder

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.