Rare diseases · Sign or symptom
Peripheral edema
HP:0012398
What it means
An abnormal accumulation of interstitial fluid in the soft tissues of the limbs.
Rare diseases that can present with this16
Common30–79%
4Sometimes5–29%
12- Acute interstitial pneumonia
- AL amyloidosis
- Atrial septal defect, ostium primum type
- Congenital heart block
- Cushing syndrome due to ectopic ACTH secretion
- Eisenmenger syndrome
- Familial idiopathic dilatation of the right atrium
- Familial isolated restrictive cardiomyopathy
and 4 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Peripheral oedema
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.