Rare diseases · Sign or symptom
Palmoplantar cutis laxa
Excessive wrinkled skin of palms and soles
HP:0007517
What it means
Loose, wrinkled skin of hands and feet.
Rare diseases that can present with this3
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Furrowed palms and soles · Increased wrinkles of palms and soles · Wrinkled palms and soles · Wrinkled skin of hands and feet
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.