Ocular anterior segment dysgenesis

What it means

Abnormal development (dysgenesis) of the anterior segment of the eye globe. These structures are mainly of mesenchymal origin.

In anterior segment mesenchymal ocular dysgenesis (ASMOD), multiple tissues are affected, including the iris, cornea, and lens as well as the Schlemm's canal and trabecular meshwork drainage structures located at the anterior segment angle where the iris and cornea meet. These abnormalities may result from a primary defect in the migration and/or differentiation of the mesenchymal cells that contribute to development of the cornea, iris, and drainage structures.

Rare diseases that can present with this3

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Anterior chamber cleavage defect · Anterior chamber cleavage disorder · Anterior chamber malformation · Anterior chamber mesodermal anomalies · Anterior segment developmental abnormality · Anterior segment dysgenesis · Anterior segment mesencyhmal dysgenesis · Anterior segment ocular dysgenesis