Rare diseases · Sign or symptom
Nephrocalcinosis
Too much calcium deposited in kidneys
HP:0000121
What it means
Nephrocalcinosis is the deposition of calcium salts in renal parenchyma.
Nephrocalcinosis can be intratubular or interstitial, and can be diagnosed by means of a radiologic exam (plain radiographs, ultrasonograms, or computed tomography scans) or via microscopic examination of the renal tissues. The term nephrocalcinosis most often applies to a generalized increase in renal calcium content.
Rare diseases that can present with this46
Very common80–99%
7Common30–79%
20- Apparent mineralocorticoid excess
- Autosomal dominant hypocalcemia
- Beckwith-Wiedemann syndrome
- Blue diaper syndrome
- Cystinosis
- Dent disease
- Generalized arterial calcification of infancy
- Hyperparathyroidism-jaw tumor syndrome
- Intellectual disability-seizures-hypophosphatasia-ophthalmic-skeletal anomalies syndrome
- Kidney tubulopathy-dilated cardiomyopathy syndrome
- Lysinuric protein intolerance
- Microvillus inclusion disease
- Oculoskeletodental syndrome
- Oncogenic osteomalacia
- Parathyroid carcinoma
- Primary hyperoxaluria
- Primary hypomagnesemia-refractory seizures-intellectual disability syndrome
- Secondary hypoparathyroidism due to impaired parathormon secretion
- Trisomy 8p syndrome
- X-linked hypophosphatemia
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Increased calcium level in kidney
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.