Rare diseases · Sign or symptom
Narrow palpebral fissure
Small opening between the eyelids
HP:0045025
What it means
Reduction in the vertical distance between the upper and lower eyelids.
Rare diseases that can present with this18
Common30–79%
5Sometimes5–29%
11- 20p13microdeletion syndrome
- Kagami-Ogata syndrome due to maternal 14q32.2 microdeletion
- Macrocephaly-developmental delay syndrome
- Microcephalic osteodysplastic primordial dwarfism type II
- Nasolacrimal duct cyst
- PDE4D haploinsufficiency syndrome
- PGM3-CDG
- Ramos-Arroyo syndrome
and 3 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased size of palpebral fissure · Narrow eyelid opening · Narrow palpebral fissures · Small palpebral fissures
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.