Rare diseases · Sign or symptom
Microcornea
Cornea of eye less than 10mm in diameter
HP:0000482
What it means
A congenital abnormality of the cornea in which the cornea and the anterior segment of the eye are smaller than normal. The horizontal diameter of the cornea does not reach 10 mm even in adulthood.
Note that the cornea's diameter is normally about 9.5-10.0 mm at birth and reaches 10.0-12-5 mm in adulthood.
Rare diseases that can present with this59
Very common80–99%
13- Cataract-microcornea syndrome
- Congenital cataracts-facial dysmorphism-neuropathy syndrome
- Ectodermal dysplasia-blindness syndrome
- Macrosomia-microphthalmia-cleft palate syndrome
- Microcephaly-microcornea syndrome, Seemanova type
- Microcornea-glaucoma-absent frontal sinuses syndrome
- Microcornea-posterior megalolenticonus-persistent fetal vasculature-coloboma syndrome
- Micro syndrome
- Nance-Horan syndrome
- Oculodentodigital dysplasia
- Oculofaciocardiodental syndrome
- Unilateral ocular duplication
- VACTERL with hydrocephalus
Common30–79%
15- Basel-Vanagaite-Smirin-Yosef syndrome
- Camptodactyly syndrome, Guadalajara type 1
- Cornelia de Lange syndrome
- Deaf blind hypopigmentation syndrome, Yemenite type
- Jacobsen syndrome
- Kyphoscoliotic Ehlers-Danlos syndrome due to lysyl hydroxylase 1 deficiency
- Lathosterolosis
- Meckel syndrome
- Microphthalmia, Lenz type
- Microphthalmia with brain and digit anomalies
- Oculocerebrofacial syndrome, Kaufman type
- Pelvis-shoulder dysplasia
- Peters plus syndrome
- Smith-Magenis syndrome
- Tetraamelia-multiple malformations syndrome
Sometimes5–29%
27- 19q13.11microdeletion syndrome
- 20p13microdeletion syndrome
- 8p11.2deletion syndrome
- Abruzzo-Erickson syndrome
- Acro-renal-ocular syndrome
- Autosomal dominant keratitis
- B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome
- Baraitser-Winter cerebrofrontofacial syndrome
and 19 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased corneal diameter
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.