Rare diseases · Sign or symptom
Metopic synostosis
HP:0011330
What it means
Premature fusion of the metopic suture.
Rare diseases that can present with this9
Sometimes5–29%
6- 9p13microdeletion syndrome
- Megalencephaly-severe kyphoscoliosis-overgrowth syndrome
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutation
- Progressive microcephaly-seizures-cortical blindness-developmental delay syndrome
- ZTTK syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Metopic craniosynostosis · Metopic suture craniosynostosis
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.