Rare diseases · Sign or symptom

Metaphyseal irregularity

Irregular wide portion of a long bone

HP:0003025

What it means

Irregularity of the normally smooth surface of the metaphyses.

Rare diseases that can present with this14

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Frayed, irregular metaphyses · Frayed, irregular, metaphyses · Irregular metaphyses · Metaphyseal fraying · Metaphyseal irregularities

Metaphyseal irregularity

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.