Rare diseases · Sign or symptom
Median cleft upper lip
Central cleft upper lip
HP:0000161
What it means
A type of cleft lip presenting as a midline (median) gap in the upper lip.
Rare diseases that can present with this22
Very common80–99%
10Common30–79%
10- Acromelic frontonasal dysplasia
- Alobar holoprosencephaly
- Fryns syndrome
- Holoprosencephaly-caudal dysgenesis syndrome
- Lobar holoprosencephaly
- Midline interhemispheric variant of holoprosencephaly
- Oculodentodigital dysplasia
- Oculomaxillofacial dysostosis
- Orofaciodigital syndrome type 2
- Semilobar holoprosencephaly
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Midline cleft lip
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.